Bone Age Determination by Ultrasound (BAUS): Validation on Brazilian Children

 Hormone Research in Paediatrics, Vol. 88, Supp 1, 2017, p 111

Prof. Carlos Alberto Longui, MD, PhD, Pediatric Endocrinology Unit Santa Casa SP School of Medicine, São Paulo, SP, Brazil, et, al. ID: NCT03190109

Conclusion (N=494):

BAUS is a safe and practical method of bone age determination, with potential clinical  applicability”.

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“Bone age assessments by Quantitative Ultrasound (SonicBone), and by Hand X-ray Based Methods are Comparable”

IMAJ, VOL19, September 2017; Page 2  (The Israel Medical Association Journal)

Rachmiel Marianna, MD 1,2, Naugolni Larisa, MD 1, Mazor-Aronovitch Kineret, MD 2,3, Koren-Morag Nira, PhD 4, Prof. Bistritzer Tzvi, MD 1,2

1Pediatric Endocrinology Clinic, Assaf Haroffeh Medical Center, Zerifin Israel, 2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel,3Pediatric Endocrinology Unit, Shebba Medical Center, Israel,  4Department of Epidemiology and Statistics, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv. Israel number NCT01346618

Conclusion (N=150):

Bone age assessment by SonicBone is comparable to the assessment by

X-ray based methods”.

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APCST 2017- Abstract submitted to the 8th Asia-Pacific Congress on Sports Technology – Tel Aviv, Oct 15 – 19, 2017):
“Evaluating Bone Age and Predicting Young Athletes’ Final Height by a Novel Ultrasound Device (Sonicbone’s BAUSportTM) and their Applications to Talent Selection, Training and Sports Medicine”.

Prof. Yuval Heled PhD1, Shmuel Levin2

1Faculty of Medicine, Tel Aviv University, Israel; Sonicbone Medical, Israel


“BAUSportTM can serve as a routine tool for implementation of more scientifically-based programs for training and injury prevention in youth athletes, with better talents selection process for various sports”.

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“Bone Age Estimation for Whom, by Whom, by Which Method?”

Prof. Zvi Laron, MD PhD. Ped. Endocrinol. Rev. 2015;13(1):444-447

Conclusion: BAUS simple technique can be used in the pediatrician’s office and could help to reach a faster diagnosis of growth problems and earlier treatment decision.

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“On the need for national, racial, or ethnic-specific standards for the assessment of bone maturation”.

Ze’ev Hochberg, MD PhD,  Eur J Endocrinol. 2015 Sep 28. pii – EJE-15-0673

Conclusion: The notion that genes are the primary determinants of physiognomy, which also includes growth-related traits, has been repeatedly disproved. Based on a fundamental understanding of phenotypic plasticity and an individual’s ability to respond to environmental cues, we do not need ethnic-specific standards for bone maturity.

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ESPE 2015 Abstract (European Society of Pediatric Endocrinology): “Quantitative Sonometeric Bone Age as a Function of Height and BMI”

Horm Res Paediatr 2015; 84 P-2-241

Alina German, MD1, Nira Koren-Morag, PhD2, Shmuel Levin3, Prof. Ze’ev Hochberg, MD, PhD 4

1Pediatric Department Bnei-Zion Medical Center and Clalit HMO, Haifa, 2Department of Epidemiology and Preventive Medicine Sackler Faculty of Medicine, Tel-Aviv University, 3SonicBone Medical Company, Rishon Lezion, Israel, 4Faculty of Medicine, Technion – Israel institute of Technology, Haifa, Israel

Conclusion (N=450, Intermediate results of study No’ 6 below):

“Shorter and thinner pubertal but not pre-pubertal children have delayed BA as compared to taller and heavier children. ii) The full-length phalanx maturation is affected by height more than the wrist and metacarpals’ epiphyses. iii) The radius-ulna epiphyses are affected by BMI more than the metacarpals and phalanx. iv) These influences have now on to be accounted for in the assessment of a BA.” 

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ESPE 2013 Abstract (European Society of Pediatric Endocrinology):
“Bone age assessment by a novel quantitative ultrasound based device, SonicBone, is comparable to the conventional Greulich and Pyle method”

Horm Res Paediatr 2013; 80(suppl 1):35

Conclusion (N=150):

SonicBone device is safe, non-invasive, radiation free and highly reproducible. Its BA assessment in a population of children attending pediatric endocrinology clinics is comparable to BA by GP method and can overcome its drawbacks”.

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